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Joint Pain

Ligament & Cartilage Regeneration

Discover a revolutionary approach to orthopedic care with AIMER at Meridius Bio. Our nanotherapeutic platform actively contributes to ligament and cartilage regeneration, advancing orthopedic solutions beyond conventional methods. AIMER not only reduces scarring but also enhances joint function, providing a holistic approach to orthopedic wellness. Backed by scientific validation, it represents a commitment to reshaping the orthopedic landscape. Explore the possibilities, embrace innovation, and welcome a new era in ligament and cartilage regeneration with AIMER at Meridius Bio.

Research backed Insight

AIMER alpha-gal nanoparticle for meniscus orthopedic applications

Role in Osteoarthritis:

The degenerative nature of osteoarthritis leads to progressive joint damage. Intra-articular injection of 100 μg α-Gal NPs (50 nm diameter) in a model of osteoarthritis promoted macrophage recruitment (2-fold) and activation (increased M2 phenotype), leading to reduced cartilage degradation (decreased MMP-13 expression) and enhanced chondrocyte proliferation (30% higher). Additionally, α-Gal NPs stimulated subchondral bone repair (increased osteoblast activity), suggesting their potential as a disease-modifying therapy for osteoarthritis.

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