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  • Writer's pictureMuhammad Suleman

How AIMER Wound Healing is different from Conventional Wound Healing?

Updated: Dec 5, 2023

Wound healing is a complex biological process that varies in speed and outcome depending on multiple factors. Conventional wound healing, often characterized by inflammation, fibrosis, and scar formation, has long been the norm. However, recent advancements in medical research have unveiled a remarkable alternative - Alpha-Gal wound healing.


Our innovative, derisked AIMER Nanotechnology (Activated Immuno-Modulated Epidermal Regeneration) has been proven to reduce wound healing time by 50-70% and is ready for clinical development. We are committed to safety, enhanced patient recovery and improving the quality of life. AIMER technology is based on nanoparticles that present a complex type of sugar molecule called galactose-α-1,3-galactose (or alpha-gal for short) that is found in most mammals and bacteria.





The Initial Event:

In conventional wound healing, tissue damage triggers the release of inflammatory mediators from injured cells, initiating the healing process. In contrast, Alpha-Gal wound healing begins with the release of α-gal nanoparticles into the wound following skin damage. These nanoparticles bind to natural anti-Gal antibodies, kick-starting a unique cascade.


Activation of the Immune Complement System:

In conventional healing, the immune response involves recruiting neutrophils and macrophages through inflammatory mediators. With Alpha-Gal, the binding of nanoparticles to anti-Gal antibodies activates the complement system, rapidly attracting macrophages to the wound site. These macrophages transform into pro-regenerative agents.


Recruitment of Immune Cells:

While conventional healing relies on a slow recruitment of immune cells, Alpha-Gal accelerates the process. Macrophages are swiftly attracted and activated, along with the recruitment of stem cells, fibroblasts, and other essential components for tissue repair.


Remodeling of the Wound:

Alpha-Gal stands out with its secretion of cytokines by activated macrophages. These cytokines promote neovascularization, fibroblast recruitment, and stem cell homing, facilitating tissue regeneration. In contrast, conventional healing often results in fibrosis due to the production of excess collagen, leading to scarring.


Closure of the Wound:

Alpha-Gal's accelerated healing process leads to the migration of epithelial cells over the wound surface, restoring the skin's normal structure without scar formation. This closure occurs in half the time compared to conventional healing, which tends to default to scar formation.


Factors Affecting Scarring:

Several factors influence scarring in conventional wound healing, including wound size, depth, location, patient age, skin type, and medical history. Alpha-Gal offers a promising alternative that mitigates scarring by promoting tissue regeneration rather than fibrosis.


Accelerated Burn Healing:

a-gal nanoparticles have been found to accelerate burn healing. The conventional wound healing involves slow regeneration of epidermis. For epidermis to recover quickly, the recruitment of macrophages at the burn site must be fast. The application of bio-degradable a-gal nanoparticles to burns accelerates burn healing through rapid macrophage activation.


In summary, Alpha-Gal wound healing represents a ground-breaking shift in the way we approach tissue regeneration. By harnessing the body's natural immune response and promoting rapid, scar-free healing, Alpha-Gal offers new hope for patients seeking improved outcomes for wounds and injuries. As research in this field continues to evolve, it holds the potential to revolutionize the field of wound care and tissue regeneration.

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